Antibiotic penetration into lung tissues. Effective antibiotic treatment for lung infections requires an amount of drug at the site of infection sufficient to achieve or.
PK/PD indices. Antibiotic physicochemical properties could be used to predict the extent of penetration into the lung tissues. Lipophilic antibiotics penetrate well.
Intravenous aminoglycosides easily penetrate in lung parenchyma and bronchial secretions according to the plasma–tissue concentration ratio. However, lung.
Until recently, information on antibiotic pharmacokinetic properties in infected human lung tissue was limited. We therefore studied a microdialysis-based.
Study objectives: To estimate the penetration of gentamicin into lung tissue by.. ) was found between gentamicin concentrations in the serum and ALF.
therapy, but the principles of antibiotic penetration.. The concentration of an antibiotic in the lung.. noglycosides penetrate poorly into lung tissue, and.
Vancomycin penetration into lung tissue was evaluated in thirty patients following .. Vancomycin is a glycopeptide antibiotic used worldwide to treat infections.
ences on antibiotic concentrations in the lung and describes a canine model for detailed pharmacologic.. areas of infected respiratory tissues in the larger.
Because distribution into tissues is dependent on the.. of drug penetration into the lung for extracellular pathogens.
High frequency of antibiotic resistance of in the specific hospital unit or.. not do in vitro due to poor penetration of aminoglycoside into lung and inactivation.. and possibly synergistic effect, good tissue penetration and reduced adverse effects.
on adequate penetration of antibiotic into the infection.. Objective: To study the penetration of tobramycin in lung tissue evaluated as the concentration in.